Morgan Escare, Ollie Roberts, Chris Atkin, Sam Luckley and Darcy Lussick come in afterward their loss to Hull FC.
Widnes name a 20-man group somewhat than the normal 21 since of damages and two first-team players separating.
Former Salford prop Lee Jewitt could make his Widnes debut after signing from Barrow last summer.
Salford (from): Escare, Sio, Watkins, Inu, Lolohea, Mossop, Ackers, Ikahihifo, Pauli, Roberts, Johnson, Atkin, Kear, Livett, Williams, Costello, Ormondroyd, Wells, Luckley, Lussick, Patton.
Widnes (from): Owens, Spedding, Tyrer, Cross, Craven, Smith, Clough, Grady, Lawton, Jewitt, Dwyer, Lyons, Roby, Edge, Buckley, Wilde, Else, Tilleke, Hill, Brookes.